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In addition, changes in glucose tolerance may also result from variants in genes that affect the gut microbiota [48], or from variants that affect gene expression through epigenetic changes
ROS are produced by multiple intrinsic mechanisms, and ROS come in a variety of forms, including radical (hydroxyl, superoxide, etc.) or non-radical (hydrogen peroxide, singlet oxygen, etc.) [25]
With that said, I typically expect (and usually see) good improvement with the 1 st round
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