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For example, mutations in the PSEN2, APP, and PSEN1 genes are associated with familial AD, while alterations in the LRRK2 gene have been correlated with familial PD
Disease-modifying effects of metabolic perturbations in ALS/FTLD
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MOTS-c is a mitochondrial-derived peptide that activates AMPK through direct mitochondrial signaling and nuclear translocation under metabolic stress, whereas metformin activates AMPK indirectly by inhibiting Complex I of the mitochondrial electron transport chain, and AICAR mimics AMP to trick the cell into AMPK activation
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