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Increased risks for GI adverse events were found for tirzepatide (HR = 1.53

Contact your healthcare provider promptly if you experience: Excessive fatigue or weakness Rapid or unexplained weight loss exceeding expected rates Severe, persistent abdominal pain (which may indicate pancreatitis) Persistent vomiting or signs of dehydration New or worsening visual symptoms (particularly if you have diabetic retinopathy) Difficulty maintaining basic daily activities Your healthcare team can assess whether metabolic changes are within expected parameters and adjust your treatment plan accordingly

Why rebound happens The drug was doing two jobs

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