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The Phase 2 trial primarily tested oral administration
Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression
Preservation of Lean Body Mass : Unlike traditional calorie-restriction models that can cause muscle loss, AOD-9604 research indicates a preservation of lean muscle tissue while reducing total body fat
The study population may have differed in meaningful ways
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