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Clinical and echocardiographic characteristics and cardiovascular outcomes according to diabetes status in patients with heart failure and preserved ejection fraction: a report from the I-preserve trial (Irbesartan in heart failure with preserved ejection fraction)

In brief, GLP-1R is found on various immune cells, and the GLP-1R signaling pathway contributes to the regulation of immune cell function

In addition, GLP-1 can boost immune cell infiltration as well as the production of pro-inflammatory cytokines under inflammatory conditions (Liu et al., 2009

This effect was observed without any impact on the marker expression of Lgr5 + stem cells, goblet cells, and Paneth cells