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Subsequent work by Pickart and Margolina identified clusters of affected genes spanning DNA repair, antioxidant defense, ubiquitinproteasome activity, anti-inflammatory signaling, and tissue remodeling [2]
The strategy of covalently conjugating metal-based anticancer agents to amphiphilic polymers, that could self-assemble into nanoparticles, could present a method for the tumor-selective anticancer therapy
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