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The reason LDN is so effective in individuals with autoimmune disease is that it addresses the root cause, turning down the volume on hyperactive immune cells and boosting anti-inflammatory endorphin signaling to provide significant symptom relief and protect the body from the damage of excess inflammation
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Lifestyle, diet and genetics all influence this pathway.*
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Emerging research shows that hypoxia actively regulates immune responses via oxygen-sensitive mechanisms in local and recruited immune cells at inflamed sites, with extensive crosstalk occurring between the hypoxia and TLR signaling pathways [212]
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