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Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimers disease
In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation
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For instance, SIRT7 has been identified as a key player in the pathogenesis of immune-mediated intestinal inflammation, specifically in inflammatory bowel disease (IBD)
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