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Based on promising evidence showing the anti-inflammatory potential of ectoine as a natural alternative or adjunctive therapy in immunological disorders, this study aimed to assess the potential anti-inflammatory and anti-rheumatic benefits of ectoine in rats with adjuvant-induced arthritis in comparison to one of the standard therapies, leflunomide, together with investigating the prospect of reversing the intestinal changes brought on by leflunomide when used in combination therapy with the osmoprotectant and membrane stabilizer ectoine

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Nicotinamide Adenine Dinucleotide (NAD+): NAD+ is a coenzyme found in the body