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Biologics modulation of lipid metabolism primarily operates through two fundamental mechanisms: (1) enhancing hepatic clearance of lipoproteins via upregulation of low-density lipoprotein receptor (LDLR) activity and (2) directly altering the composition, modification, and metabolism of atherogenic lipoproteins

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They also have a boxed warning regarding thyroid C-cell tumors observed in rodents (though human relevance remains uncertain)

The injections are well-tolerated, with most patients describing them as less uncomfortable than standard insulin injections