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By pre-treating rats with the non-specific cholinergic receptor antagonist atropine as well as the specific M3 cholinergic receptor antagonist 4-DAMP and performing vagotomy, the researchers found that atropine and 4-DAMP significantly reduced metformin-induced GLP-1 secretion, whereas vagotomy had no effect on metformin-induced GLP-1 secretion

However, the impact that psyllium husk has on GLP-1 is negligible compared to the impact that taking a GLP-1 medication has on our appetite suppression and weight loss, she says

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