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The change in pH of TSB and 1 PBS at different GSH concentrations was determined using a pH meter (Mettler-Toledo GmbH, Greifensee, Switzerland) calibrated with pH standards of 4.0 and 7.0 and the pH values of TSB and 1 PBS as a function of GSH concentration reported in Table 2

Glucagon-like peptide-1 (GLP-1) is a peptide secreted by the intestinal tract after the stimulation of food intake, which induces the secretion of insulin by cells, thus modulating blood glucose (12)

In the SURPASS and SURMOUNT trials, nausea was reported in up to 32% of participants, diarrhea in 23%, vomiting in 12%, and constipation in 11%

The altered metabolism and GI effects persist throughout the week