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Risk differences were attenuated among metformin monotherapy users (2.0 and 4.1) compared with users of 2 or more diabetes medications (5.7 and 4.0) versus SGLT2is and DPP4is, respectively
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It simultaneously restores gut microbiota balance, enriching beneficial bacteria such as Lactobacillus while suppressing harmful species
Similarly, the SURMOUNT-4 trial showed substantial weight regain following tirzepatide discontinuation
