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The Three Generations of Incretin Peptide Research The progression from single to dual to triple agonist peptides represents a research trajectory that has played out in roughly ten years: Generation 1 Single GLP-1 Agonists (Semaglutide, Liraglutide, Exenatide) The first incretin peptides to reach broad clinical research were GLP-1 receptor agonists

[18] [19] Separate Phase 2 data in people with type 2 diabetes (also published in The New England Journal of Medicine , 2023) showed meaningful reductions in HbA1c alongside significant weight loss, suggesting potential utility across metabolic disease

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