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lncRNA PICSAR alters cell proliferation, migration, invasion, IL-6, IL-8, and MMP-3 production through sponging miR-4701-5p, in other words, lncRNA PICSAR can competitively combine miR-4701-5p to affect downstream target genes (257)
In the NEJM Phase 2 trial, participants assigned to an initial dose of 4 mg experienced significantly more adverse events than those who started at 2 mg, even when both groups ultimately reached the same target dose
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