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Advantages of metformin include the longstanding research supporting its efficacy and safety, an expected decrease in the glycated hemoglobin (HbA1c) level of 1% to 1.5%, low cost, minimal hypoglycemic risk, and potential reductions in cardiovascular (CV) events due to decreased low-density lipoprotein (LDL) cholesterol
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This overlap with the mTOR axis places MOTS-c in an interesting relationship with The Rapamycin Protocol, the most direct pharmaceutical intervention on the mTOR pathway
Curr Opin Behav Sci
"While the data presented at CTAD was disappointing, pursuing this type of high-risk, high-reward research into Alzheimer's pathobiology is essential to deepening our understanding of the disease and continuing to advance the science," said Howard Fillit, MD, Co-Founder and Chief Science Officer of the Alzheimer's Drug Discovery Foundation (ADDF)
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