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Nagai M et al (2012) The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells
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Increased levels of miR-144 have been found in a subset of HbSS patients with typical severe anemia and reduced NRF2 protein levels, causing a reduction of GSH regeneration and impairing cell response to OS, thereby providing a possible mechanism for the increased anemia severity seen in these patients [221]
The maximum weekly cagrilintide dose studied in clinical trials is 4.5 mg for monotherapy
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