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The broader GLP-1 class literature -- and the Phase 2 retatrutide data specifically -- documents that weight regain is common after discontinuation

Similarly, Goto showed that exendin-4 reduced intimal thickening after vascular injury by the suppression of platelet-derived growth factor-induced proliferation in isolated murine, rat and human aortic vascular smooth muscle cells [102]

Joshi, K., Kirby, A., Niu, J