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It binds to growthhormone secretagogue receptors (GHSR) in the hypothalamus and pituitary, reduces the inhibitory signal from somatostatin, and triggers a rapid GH pulse
Front Immunol 10:277
Indirect comparisons using network meta-analysis suggest tirzepatide 15 mg produces approximately 5, 6 percentage points greater weight loss than semaglutide 2.4 mg, but trial populations differ in ways that complicate direct comparison
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