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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

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Original research focused primarily on those with diabetes, but a recent study found an increased risk of stomach paralysis for non-diabetic patients who used medications like Ozempic, Wegovy, Rybelsus, and Saxenda for weight loss