While both treatments might theoretically benefit GERD symptoms, only BPC-157 addressed the underlying sphincter dysfunction driving the condition
However, incomplete -oxidation leads to the accumulation of long-chain acylcarnitines, which may be linked to mitochondrial dysfunction, further intensifying hepatic fat deposition 37
For athletes or active individuals, its benefits lie primarily in fat mass reduction and appetite regulation , though it does not appear to preserve lean body mass to the same degree suggested in Tirzepatide trials
The phase 2b SYMMETRY trial, a multicenter, randomized, double-blind, placebo-controlled study, included 181 patients with compensated cirrhosis (Child-Pugh A) due to MASH (78% with histological diagnosis and 22% with cryptogenic cirrhosis attributed to MASH) assigned to receive efruxifermin at doses of 28 or 50 mg, or placebo (1:1:1), for 96 weeks