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a meta-analysis of random trials found that patients treated with these medications experience an elevated overall risk of hospitalization due to heart failure, while other researchers have found this trend in increased hospital admission to be nonsignificant

In this prospective, double-blind trial in 304 patients with T2DM and coronary artery disease, subjects randomized to metformin or glipizide for 3 years obtained similar glycemic control (average A1C of 7.0% and 7.1%, respectively)

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(No such studies are required for Ozempic.) Meanwhile, millions of people will take the drugs, including during pregnancy