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doi:10.3390/ijms26062691 Gatta M, Dovizio M, Milillo C, et al
doi: 10.1016/j.neuint.2021.105042 48 MontagneA.BarnesS
Hydroxocobalamin regimen (UK example): 1 mg (1000 g) IM three times a week for 2 weeks (loading), then 1 mg every 3 months thereafter
The protocol successfully generated hepatocytes from cGMP cell lines using small molecules combined with growth factors in 21 days ( ALB expression was detected but insignificant in the induced hepatocytes, suggesting that the hepatocytes was immature ( ALB positive hepatocytes account for 67.7% versus 37.1% in the growth factor group ( 3.2 Small molecules for direct reprogramming to hepatic lineage Recently, studies have shown that somatic cells can be directly reprogrammed into specific cell lineage, including hepatocytes
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