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Conversely, isoniazid and pyrazinamide (tuberculosis drugs) are structural analogs of niacin that can interfere with niacin metabolism, potentially precipitating pellagra in rare cases
[9] High-dose niacin (used to treat cholesterol) lacks human safety data in pregnancy and could theoretically affect the fetus (for example, by causing hypotension or altering lipid metabolism)
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observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )
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