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Absorption variability is another consideration

This article explores why weight loss plateaus happen and how to restart your weight loss progress

The primary mechanisms include: Enhanced insulin secretion in response to elevated blood glucose levels, helping to lower blood sugar in people with type 2 diabetes Suppression of glucagon release from the pancreas, reducing glucose production by the liver Delayed gastric emptying , which slows the movement of food from the stomach into the small intestine Increased satiety through actions on appetite centres in the brain, leading to reduced food intake The slowing of gastric emptying is particularly significant when considering electrolyte balance

If maintenance dose data supports it, a long-term strategy might look like this: titrate to 8-12mg for 48-68 weeks of active weight loss, then step down to 4-6mg for indefinite maintenance