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Botox creates more rigid commitment requiring quarterly treatments for maintenance with complete wrinkle return if stopping, though self-limiting nature means discontinuation remains option without permanent consequences beyond returning to pre-treatment baseline

This is the strongest peer-reviewed human evidence in the T4 family, although the formulation tested was full-length T4, not the TB-500 fragment

In testes, inflammatory mediators can interfere with Leydig cell function and inhibit testosterone production

As always, results will vary, and this is not specific medical advice designed to diagnose or cure any ailment or disease