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Before we could continue our investigation, however, we wished to validate a published dopamine depletion model [25]

We recommend rotating injection sites by at least 2 cm to prevent irritation and also avoiding injecting KLOW into bruised or damaged skin

While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides