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Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision

Treatment of tanned skin increases the complication rate and should be avoided

It is studied in research for its effects on increasing satellite cell proliferation, lowering cholesterol, inflammation reduction, and decrease of neuro-degeneration