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Unlike the endogenous ligands, which have short half-life, rapid degradation by dipeptidyl peptidase-4 (DPP-4) enzyme and undesirable side effects, such as hypoglycemia and nausea (Drucker, 2023, Nature), retatrutide has been engineered to overcome these limitations

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A team of researchers developed a nanostructure-based GLP-1R agonist capable of crossing the BBB that significantly attenuated neuroinflammation and memory loss in an A peptide-induced mouse model of AD by inhibiting the inflammatory responses of microglia and astrocytes (Zhao et al., 2022)