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For the hepsin / mice, the timing of mortality was such that it occurred prior the onset of liver repair and regeneration processes, thereby confirming the role of hepsin in determining the mechanism of APAP toxicity tolerance during the early phase of drug exposure

Although the results suggest that KD exacerbates biotin deficiency in mice, human clinical studies are needed to confirm these observations (249)

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However, understanding realistic expectations is essential before beginning any treatment