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An inflammatory signal, folded into silence

Additional investigations explore melanocortin system involvement in metabolism, appetite regulation, and behavioral signaling pathways

A separate study following participants from the STEP 1 clinical trial found that weight, waist circumference and cardiometabolic risk factors largely returned toward baseline levels within 12 months of stopping the medication

Cumulative: ~1825 kg Journey: still ongoing best results at 1218 months The maintenance phase where maximum results are achieved Dose: 15mg (or optimal maintenance dose) This is the section most before-and-after guides ignore and it is the most important for patients wanting to understand what Mounjaro actually delivers long-term