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Metformin may produce modest weight loss of 4-7 pounds over 6-12 months in patients with Hashimoto's who have concurrent insulin resistance or prediabetes, though it is not FDA-approved for this indication

Taken together, evidence from neuroscience, human research, and clinical practice suggests meaningful overlap between obesity and addiction-related mechanisms. Leggio says that his lab has long been interested in how gut-brain neuroendocrine pathways may influence alcohol use disorder (AUD)

TB-500 amplifies that response and extends it across multiple tissue types at once