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Its not clear why, but a review of over 40 years of research, published in Annals of Medical and Health Sciences Research, concludes that its likely due to a combination of increased exposure to air pollution and more GI infections during summer months

2.21 Cytochrome P450 (CYP)-linked monooxygenases Pentoxyresorufin O-dealkylase (CYP2B1/2), ethoxyresorufin O-deethylase (CYP1A1) and methoxyresorufin O-demethylase (CYP1A2) were estimated using pentoxyresorufin, ethoxyresorufin and methoxyresorufin as substrates, respectively, and monitoring the formation of resorufin as final reaction product was monitored by the use of Perkin Elmer LS 50 B Luminescence spectrometer

Research showed that people taking a daily 14 mg oral dose experienced an average A1C reduction of 1.2% after about 6 months (26 weeks)