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GLP-1 has a very short half-life of approximately 1-2 minutes in circulation, as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)
Furthermore, we need to continue to broaden our understanding of the physiologic effects of these medications to optimize patient safety and overall outcomes. Rona said the next best research step would be to perform randomized-controlled trials in humans to further analyze the effects of GLP-1 medications on lean mass as well as skeletal muscle mass
Metformin Common side effects of metformin include stomach upset, stomach pain, gas, bloating, nausea, and diarrhea affecting up to 30% of patients on immediate-release formulations
Rather than leaning on one mechanism, it's built to support the whole recovery process at once
