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The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses

Hypotheses Res

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In accordance with this hypothesis, treating infected leafhopper testes with a specific dose of proteasome inhibitor results in an increase in Pelo and Hbs1 levels, indicating that the proteolytic degradation pathway is responsible for the reduced regulation of Pelo level under viral infection