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The efficacy and safety of acetyl-l-carnitine (500 mg three times a day) versus methylcobalamin (0.5 mg three times a day) to treat diabetic peripheral neuropathy was assessed in a Chinese multicentre, randomised, parallel-group, double-blind, double-dummy, positive-controlled, non-inferiority phase II clinical trial
Endotoxins and non-alcoholic fatty liver disease
Neuromuscul Disord 30(6):492502 Giovarelli M, Zecchini S, Casati SR, Lociuro L, Gjana O, Mollica L et al (2025) The SIRT1 activator SRT2104 exerts exercise mimetic effects and promotes Duchenne muscular dystrophy recovery
in Clinical Pharmacology & Therapeutics found subcutaneous injection reached peak plasma concentration (Tmax) at 75 minutes versus 38 minutes for IM, but area-under-curve (total bioavailability) was statistically equivalent at 94% versus 97%
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