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The regulatory effect of NRF2 on those genes was well documented through antioxidative response element binding in the promoter or enhancers of target genes
Together these interactions link TMs 2,3 and 4 (Fig
A chemical peel can also be used to treat the acne-like bumps that rosacea can cause, by exfoliating the top layer of the skin, which is then replaced by new, healthier skin cells
However, vitamin C does not reach the levels necessary to significantly affect the skin because it is frequently the last organ to absorb it
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