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The Neurovascular Unit as a Metabolic and Structural Barrier The BBB functions essentially as a highly specialized metabolic organ

In fact, those who are low in vitamin B12 can benefit from supplementing with higher doses of this water-soluble vitamin (vitamins that your body doesnt store in its tissues)

Certain medical conditions and medications increase B12 requirements: Long-term use of metformin (diabetes medication) or proton pump inhibitors (PPIs for acid reflux) can impair B12 absorption [13] [14] Gastrointestinal conditions such as Crohn's disease, coeliac disease, or previous gastric surgery Autoimmune conditions beyond pernicious anaemia may affect B12 metabolism When to contact your GP : If you are taking B12 supplements or receiving injections but continue to experience symptoms, request a review

2A), the corresponding reduction of ROS generation was 47% (Supplementary Fig