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The standard dosing schedule builds up slowly for this reason, and some providers use even more gradual approaches for patients who are particularly sensitive
Its a lot of water
Heterozygotes (1 per 500 people) typically exhibit a 30% increase in the duration of skeletal muscle blockade after a standard dose of succinylchloline, whereas homozygotes (1 per 2000 to 5000 people) can experience 2-3 hours of neuromuscular blockade (Thomsen et al, 2015
Philos Trans R Soc London B
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