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And while these trials are important to understanding the safety and efficacy of drugs, "no randomized controlled trial" is not the same as "no evidence." We have the accumulated experience of thousands of clinicians who have prescribed these compounds for nearly a decade and watched real patients get better in real time

Always consult a licensed healthcare provider before starting or changing hormone therapy

References References Selective and membranepermeable small molecule inhibitors of NNMT Roles of Nicotinamide NMethyltransferase in Obesity and Type 2 Diabetes Nicotinamide Nmethyltransferase inhibition mimics and boosts exercisemediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al

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