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Existing diabetic retinopathy, especially moderate or worse stages Hemoglobin A1c above 10 percent before starting semaglutide A1c drops of more than 2 percentage points within three months Previous episodes of diabetic macular edema or retinal bleeding Long duration of diabetes, typically more than ten years Eye Symptoms to Watch For While Taking Semaglutide Vision that changes from day to day or even hour to hour often signals shifting fluid levels in your retina or temporary changes in your lens shape

GLP-1 RAs promotes weight loss primarily by decreasing appetite and caloric intake, rather than by increasing energy expenditure

This causes excessive calcium to enter neurons, damaging mitochondria and triggering cell death (Arnold et al., 2024)

Transgenic Res 33(5):427443