Polyphenols can prevent ototoxicity of cisplatin by improving cellular antioxidant homeostasis, modulating signaling pathways, mitigating inflammatory responses, and ameliorating the disruption of cisplatins intra-auricular environment in a dose- and time-dependent manner (Maiuolo et al., 2022).Moreover, after studies of natural compounds with anti-tumor properties, polyphenols have emerged as strong chemotherapeutic sensitization candidates (Vladu et al., 2022
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Puerarin is known for its several pharmacological actions, which include vasodilation, cardioprotection, neuroprotection, and antioxidant capabilities
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