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Almost every property that distinguishes it from an ordinary short peptide, its color, its pH sensitivity, its incompatibility with chelators and reducing agents, its awkward behavior in mass spectrometry and reversed-phase chromatography, is a property of the metal center rather than of the peptide
Research has investigated its interactions with nitric oxide (NO) pathways, growth factor modulation (including VEGF and EGF), and the FAK-paxillin signaling cascade involved in tissue remodeling studies
- Bioactivity drops from 100 percent to near zero
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