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Published Phase 2 effect sizes most prominently the ~24 percent mean body weight reduction at the 12 mg dose tier in the obesity Phase 2 (PMID 37366315) exceed those reported for dual or single agonists at comparable durations, an outcome that researchers attribute to the additional glucagon-arm contribution to body-composition and energy-expenditure pathways
McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, Flatt PR
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Clinical testing showed a 23% increase in net elasticity and a 22% improvement in firmness after 12 weeks measurable results that translate to tighter, more supple skin
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