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For example, mesenchymal stem cell-derived cytokines have been shown to modulate astrocytic responses, with IL-6 preventing the progression of astrocyte reactivity following ischemic brain injury through the activation of the AMPKmTOR signaling pathway 145
Following an overview of upstream drivers including lung-gut microbiome dysbiosis and Th17/Treg immune imbalance, the downstream effector network of IL-17A is analyzed
But for many patients, these settle with time
Oxidative stress is also closely linked to mitochondrial dysfunction and despite findings are not consistent, it seems that deleted mitochondrial DNA is a manifestation in postmortem brains of patients with BD, which can be equally related to calcium dysregulation [43]
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