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249 Furthermore, 5-FU/cisplatininduced interferon responses upregulate ADAR1 via JAK/STAT, promoting A-to-I RNA editing that stabilizes SCD1 mRNA, reprograms lipid metabolism, activates Wnt/-catenin signaling, and sustains stemness and chemoresistance in gastric cancer
To reduce the danger of negative responses, we prioritise the safety and quality of our goods
In clinical trials, doses are escalated gradually over several weeks to improve tolerability a process known as dose titration
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