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It flags a different set of signs as needing prompt attention: persistent reactions, signs of infection, or unexplained changes in treatment response, all of which it says warrant immediate provider contact rather than waiting it out

In clinical trials, retatrutide has shown larger average weight reductions (~30%) than tirzepatide (~21%) or semaglutide (~15%), which researchers attribute to its additional glucagon receptor activity

Severe persistent headaches, unusual symptoms not typically associated with AOD 9604, or anything that significantly impairs daily function should prompt stopping

One major study is looking at heart health, specifically whether CagriSema can reduce the risk of heart attacks and strokes in people with existing heart disease