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Unlike semaglutide, which activates only the GLP-1 receptor, or tirzepatide, which targets both GLP-1 and GIP, retatrutide engages three key metabolic receptors simultaneously: GLP-1 receptor curbs appetite, slows gastric emptying, and lowers blood sugar
Because semaglutide and tirzepatide affect blood glucose levels and cardiovascular function, most donation centers classify them as medications requiring medical review before donation eligibility can be determined
2010 Nov;45(11):1111-20
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