Split dosing (dividing the daily amount into two injections, morning and evening) maintains more consistent tissue levels throughout the day
Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome
Contact your GP, healthcare provider, or if you need urgent advice NHS 111 if you experience: A persistent resting heart rate above 100 bpm (resting tachycardia) Palpitations a sensation of a racing, fluttering, or pounding heartbeat Dizziness, light-headedness, or near-fainting episodes Chest discomfort or tightness, particularly if associated with exertion Shortness of breath that is new or worsening Fatigue that is disproportionate to your level of activity Seek emergency medical attention (call 999 or go to A&E) if you experience: Chest pain radiating to the arm, jaw, or back Sudden severe breathlessness Loss of consciousness or collapse A very rapid or irregular heartbeat that does not settle within a few minutes Some symptoms, such as mild palpitations or a sensation of a faster heartbeat, may be transient and occur particularly after dose escalation
Thymosin beta-4 has human clinical data, but TB-500 itself does not have completed human musculoskeletal trials