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Formulation vehicle: Lipid-based vehicles outperform water-based serums for absorption
Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]
Some non-dairy milks, like almond and rice milk, are also fortified with B12
Moving forwards, it would be beneficial for further research to progress to larger animal models
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